Technology Mapping for Circuit Optimization Using Content-Addressable Memory

The growing complexity of Field Programmable Gate Arrays (FPGA's) is leading to architectures with high input cardinality look-up tables (LUT's). This thesis describes a methodology for area-minimizing technology mapping for combinational logic, specifically designed for such FPGA architectures. This methodology, called LURU, leverages the parallel search capabilities of Content-Addressable Memories (CAM's) to outperform traditional mapping algorithms in both execution time and quality of results. The LURU algorithm is fundamentally different from other techniques for technology mapping in that LURU uses textual string representations of circuit topology in order to efficiently store and search for circuit patterns in a CAM. A circuit is mapped to the target LUT technology using both exact and inexact string matching techniques. Common subcircuit expressions (CSE's) are also identified and used for architectural optimization---a small set of CSE's is shown to effectively cover an average of 96% of the test circuits. LURU was tested with the ISCAS'85 suite of combinational benchmark circuits and compared with the mapping algorithms FlowMap and CutMap. The area reduction shown by LURU is, on average, 20% better compared to FlowMap and CutMap. The asymptotic runtime complexity of LURU is shown to be better than that of both FlowMap and CutMap

Red material on the large moons of Uranus: Dust from irregular satellites?

The large and tidally-locked classical moons of Uranus display longitudinal and planetocentric trends in their surface compositions. Spectrally red material has been detected primarily on the leading hemispheres of the outer moons, Titania and Oberon. Furthermore, detected H2O ice bands are stronger on the leading hemispheres of the classical satellites, and the leading/trailing asymmetry in H2O ice band strengths decreases with distance from Uranus. We hypothesize that the observed distribution of red material and trends in H2O ice band strengths results from infalling dust from Uranian irregular satellites. These dust particles migrate inward on slowly decaying orbits, eventually reaching the classical satellite zone, where they collide primarily with the outer moons. The latitudinal distribution of dust swept up by these moons should be fairly even across their southern and northern hemispheres. However, red material has only been detected over the southern hemispheres of these moons (subsolar latitude 81 S). Consequently, to test whether irregular satellite dust impacts drive the observed enhancement in reddening, we have gathered new ground-based data of the now observable northern hemispheres of these moons (sub-observer latitudes, 17 to 35 N). Our results and analyses indicate that longitudinal and planetocentric trends in reddening and H2O ice band strengths are broadly consistent across both southern and northern latitudes of these moons, thereby supporting our hypothesis. Utilizing a suite of numerical best fit models, we investigate the composition of the reddening agent detected on these moons, finding that both complex organics and amorphous pyroxene match the spectral slopes of our data. We also present spectra that span 2.9 to 4.1 microns, a previously unexplored wavelength range in terms of spectroscopy for the Uranian moons.Comment: Icarus [In Press]. 12 figures, 15 table

Promises and Pitfalls of Mobile Money in Afghanistan: Evidence from a Randomized Control Trial

ABSTRACT Despite substantial interest in the potential for mobile money to positively impact the lives of the poor, little empirical evidence exists to substantiate these claims. In this paper, we present the results of a field experiment in Afghanistan that was designed to increase adoption of mobile money, and determine if such adoption led to measurable changes in the lives of the adopters. The specific intervention we evaluate is a mobile salary payment program, in which a random subset of individuals of a large firm were transitioned into receiving their regular salaries in mobile money rather than in cash. We separately analyze the impact of this transition on both the employer and the individual employees. For the employer, there were immediate and significant cost savings; in a dangerous physical environment, they were able to effectively shift the costs of managing their salary supply chain to the mobile phone operator. For individual employees, however, the results were more ambiguous. Individuals who were transitioned onto mobile salary payments were more likely to use mobile money, and there is evidence that these accounts were used to accumulate small balances that may be indicative of savings. However, we find little consistent evidence that mobile money had an immediate or significant impact on several key indicators of individual wealth or well-being. Taken together, these results suggest that while mobile salary payments may increase the efficiency and transparency of traditional systems, in the short run the benefits may be realized by those making the payments, rather than by those receiving them

Exhaled nitric oxide: a marker of pulmonary hemodynamics in heart failure

AbstractObjectivesWe sought to test the hypothesis that patients with decompensated heart failure (HF) lose a compensatory process whereby nitric oxide (NO) maintains pulmonary vascular tone.BackgroundExhaled nitric oxide (eNO) partially reflects vascular endothelial NO release. Levels of eNO are elevated in patients with compensated HF and correlate inversely with pulmonary artery pressures (PAP), reflecting pulmonary vasodilatory activity.MethodsWe measured the mean mixed expired NO content of a vital-capacity breath using chemiluminescence in patients with compensated HF (n = 30), decompensated HF (n = 7) and in normal control subjects (n = 90). Pulmonary artery pressures were also measured in patients with HF. The eNO and PAP were determined sequentially during therapy with intravenous vasodilators in patients with decompensated HF (n = 7) and in an additional group of patients with HF (n = 13) before and during administration of milrinone.ResultsThe eNO was higher in patients with HF than in control subjects (9.9 ± 1.1 ppb vs. 6.2 ± 0.4 ppb, p = 0.002) and inversely correlated with PAP (r = −0.81, p < 0.00001). In marked contrast, patients with decompensated HF exhibited even higher levels of eNO (20.4 ± 6.2 ppb) and PAP, but there was a loss of the inverse relationship between these two variables. During therapy (7.3 ± 6 days) with sodium nitroprusside and diuresis, hemodynamics improved, eNO concentrations fell (11.2 ± 1.2 ppb vs. before treatment, p < 0.05), and the relationship between eNO and PAP was restored. After milrinone, eNO rose proportionally with decreased PAP (p < 0.05).ConclusionsElevated eNO may reflect a compensatory circulatory mechanism in HF that is lost in patients with clinically decompensated HF. The eNO may be an easily obtainable and quantifiable measure of the response to therapy in advanced HF

Eclipse-Ballooning 2017: The U of MN – Twin Cities Experience

The stratospheric ballooning team at the U of MN – Twin Cities started working on eclipse-ballooning in the fall of 2013, even before the Montana Space Grant announced their plan to organize a national Eclipse Ballooning Project. Our team promptly signed up to assist their effort, and have been heavily involved ever since. This presentation will discuss our eclipse-ballooning efforts and progress over the past 4 years. Our experiences include experimenting with a GoPro-based video-telemetry system (which ultimately was not as successful as Montana’s Raspberry-Pi-based system), adopting (then helping test, modify, and teach other teams to learn to use) the Montana telemetry system, practicing with up-range and down-range ground station placement, developing and testing passive anti-rotation devices and active camera-pointing devices to improve video quality, landing two eclipse-telemetry systems in Minnesota lakes one week before the eclipse (ouch!), flying five balloon stacks during the eclipse from near Grand Island, NE, and organizing/hosting AHAC 2017. We will also discuss ways in which we have already begun to use the telemetry equipment for non-eclipse balloon missions. The eclipse project has greatly expanded our HAB network and ballooning capabilities in multiple different directions, and will continue to strongly influence our stratospheric ballooning program for years to come

Transit Timing Observations from Kepler: III. Confirmation of 4 Multiple Planet Systems by a Fourier-Domain Study of Anti-correlated Transit Timing Variations

We present a method to confirm the planetary nature of objects in systems with multiple transiting exoplanet candidates. This method involves a Fourier-Domain analysis of the deviations in the transit times from a constant period that result from dynamical interactions within the system. The combination of observed anti-correlations in the transit times and mass constraints from dynamical stability allow us to claim the discovery of four planetary systems Kepler-25, Kepler-26, Kepler-27, and Kepler-28, containing eight planets and one additional planet candidate.Comment: Accepted to MNRA

Silvestrol exhibits significant in vivo and in vitro antileukemic activities and inhibits FLT3 and miR-155 expressions in acute myeloid leukemia

BACKGROUND: Activating mutations [internal tandem duplication (ITD)] or overexpression of the FMS-like tyrosine kinase receptor-3 (FLT3) gene are associated with poor outcome in acute myeloid leukemia (AML) patients, underscoring the need for novel therapeutic approaches. The natural product silvestrol has potent antitumor activity in several malignancies, but its therapeutic impact on distinct molecular high-risk AML subsets remains to be fully investigated. We examined here the preclinical activity of silvestrol in FLT3-ITD and FLT3 wild-type (wt) AML. METHODS: Silvestrol in vitro anti-leukemic activity was examined by colorimetric cell viability assay, colony-forming and flow cytometry assays assessing growth inhibition and apoptosis, respectively. Pharmacological activity of silvestrol on FLT3 mRNA translation, mRNA and protein expression was determined by RNA-immunoprecipitation, qRT-PCR and immunoblot analyses, respectively. Silvestrol in vivo efficacy was investigated using MV4-11 leukemia-engrafted mice. RESULTS: Silvestrol shows antileukemia activity at nanomolar concentrations both in FLT3-wt overexpressing (THP-1) and FLT3-ITD (MV4-11) expressing AML cell lines (IC(50) = 3.8 and 2.7 nM, respectively) and patients’ primary blasts [IC(50) = ~12 nM (FLT3-wt) and ~5 nM (FLT3-ITD)]. Silvestrol increased apoptosis (~4fold, P = 0.0001), and inhibited colony-formation (100%, P < 0.0001) in primary blasts. Silvestrol efficiently inhibited FLT3 translation reducing FLT3 protein expression by 80–90% and decreased miR-155 levels (~60%), a frequently co-regulated onco-miR in FLT3-ITD-positive AML. The median survival of silvestrol-treated vs vehicle-treated mice was 63 vs 29 days post-engraftment, respectively (P < 0.0001). CONCLUSIONS: Silvestrol exhibits significant in vivo and in vitro antileukemic activities in AML through a novel mechanism resulting in inhibition of FLT3 and miR-155 expression. These encouraging results warrant a rapid translation of silvestrol for clinical testing in AML

LSST Science Book, Version 2.0

A survey that can cover the sky in optical bands over wide fields to faint magnitudes with a fast cadence will enable many of the exciting science opportunities of the next decade. The Large Synoptic Survey Telescope (LSST) will have an effective aperture of 6.7 meters and an imaging camera with field of view of 9.6 deg^2, and will be devoted to a ten-year imaging survey over 20,000 deg^2 south of +15 deg. Each pointing will be imaged 2000 times with fifteen second exposures in six broad bands from 0.35 to 1.1 microns, to a total point-source depth of r~27.5. The LSST Science Book describes the basic parameters of the LSST hardware, software, and observing plans. The book discusses educational and outreach opportunities, then goes on to describe a broad range of science that LSST will revolutionize: mapping the inner and outer Solar System, stellar populations in the Milky Way and nearby galaxies, the structure of the Milky Way disk and halo and other objects in the Local Volume, transient and variable objects both at low and high redshift, and the properties of normal and active galaxies at low and high redshift. It then turns to far-field cosmological topics, exploring properties of supernovae to z~1, strong and weak lensing, the large-scale distribution of galaxies and baryon oscillations, and how these different probes may be combined to constrain cosmological models and the physics of dark energy.Comment: 596 pages. Also available at full resolution at http://www.lsst.org/lsst/sciboo